Who We Are

Precision Medicine CanPREVENT AMR:

Applying precision medicine technologies in Canada to prevent antibody-mediated rejection and premature kidney transplant loss

Project Highlights

Project Leaders

  • Paul Keown (UBC)
  • Ruth Sapir-Pichhadze
    (McGill University)
  • Timothy Caulfield (University of Alberta)
  • Stirling Bryan (UBC)

Genome Centres

  • Genome British Columbia (administrative lead)
  • Génome Québec
  • Genome Alberta

Total Funding

  • $10.8 million
  • Total Funding In-kind contribution from private and industrial stakeholders 

Our Story

The team led by Drs. Paul Keown and Stirling Bryan of the University of British Columbia, Ruth Sapir-Pichhadze of McGill University and Timothy Caulfield of the University of Alberta which includes over 70 scientists and clinicians from 22 universities in Canada, the US, the UK and the EU will use genomic technologies to reduce the risk of AMR.

These will enable better matching of patients and donors, precise monitoring of the immune response after transplantation to better predict AMR, and the use of personalized drug treatments to prevent rejection while avoiding infection or cancer. The team will also engage patients, providers and health care payers to study the legal, ethical, societal and economic considerations of introducing these strategies into clinical practice.

our story - gctc
transplants in canada - gctc

Our Goal

The goals of the research program are:
First, to reduce the frequency of AMR by at least 50 percent and to benefit the patient and his or her family through improved survival and quality of life and also to reduced caregiver burden and personal health costs;

Second, to minimize demand on the health-care system by reducing costs through decreasing dialysis and re-transplantation;

Third, to improve societal care of a major chronic disease by increasing productivity and streamlining the management of chronic kidney failure. This program offers the possibility to reduce health care costs by $1 billion over the next 15 years.

Our Goal

The goals of the research program are:

First, to reduce the frequency of AMR by at least 50 percent and to benefit the patient and his or her family through improved survival and quality of life and also to reduced caregiver burden and personal health costs;
Second, to minimize demand on the health-care system by reducing costs through decreasing dialysis and re-transplantation;

Third, to improve societal care of a major chronic disease by increasing productivity and streamlining the management of chronic kidney failure. This program offers the possibility to reduce health care costs by $1 billion over the next 15 years.

transplants in canada - gctc

Transplant in Canada

Canada is in a unique position to research and resolve the problem of antibody rejection in transplants, having achieved a major milestone – our national standardization of antibody testing is the envy of the transplant world. Not only has this allowed us to match donor organs to patients that were previously difficult to transplant, this approach is now the foundational element that allows us to define novel strategies to prevent antibodies from being formed or harming transplants in all patients.

The development of antibodies causing rejection is a problem that has vexed clinicians and scientists since the very beginning of transplantation. Now, through the convergence of new genomic technologies, precise antibody testing standardization and our national network of experts that bridges research to clinical needs, we are finally able to implement real solutions. This is an exciting new and hugely important opportunity for our patients and will again reinforce Canada’s important global role at the forefront of transplantation.

our story - GCTC

Team Highlights

Newest Members

Paaksum Wong

Karolina Jones 

Louisa Edwards

Project Leaders

We have built our team specifically to capitalise on the expertise and experience of investigators who are world leaders in regulation and biomarker development (FDA), genetics and histocompatibility, genome sciences, pharmacometrics, clinical transplantation, health economics and provider program management, from many countries including Canada, the US, EU and UK.

By drawing together an international multidisciplinary team of world-class scientists linked by long personal collaboration working in outstanding facilities, we anticipate the highest chance of success in this endeavour.

paul keown -gctc

PAUL A. KEOWN

PROF. MD, DSC, MBA

Dr Ruth Sapir - GCTC

RUTH SAPIR-PICHHADZE

BMEDSC, MD, MSC, PHD, FRC PC

TIMOTHY CAULFIELD

BSC, LLB, LLM

STIRLING BRYAN

PHD

Our Research Team

Research Members: Activity 1

Title: Professor, University of British Columbia (UBC), Medicine and Pathology, Director, Immunology & Founding Head, BC Transplant Program

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.

Title: Scientist, RI-MUHC, Assistant Professor, Department of Medicine, Faculty of Medicine, McGill University

Role: Expert in clinical transplantation, clinical epidemiology, and HLA epitopes.

Title: Emeritus Professor of Pathology, University of Pittsburgh School of Medicine

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and application to, clinical transplant.

Title: Consultant Clinical Scientist at Royal Liverpool Hospital and Professor, University of Liverpool

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics
Transplantation, directing clinical laboratory website data collection

Title: U. London, Professor of Immunogenetics, Director of Bioinformatics, Anthony Nolan Research Centre, President International HLA & Immunogenetics Workshop & Conference

Role: Expert in HLA, immunogentics, genomics, bioinformatics, international data integration and analysis, sequencing and epitope analysis

Title: RI-MUHC, Head of Genome Sciences, McGill U, Professor of Human Genetics

Role: Expert in genome sciences, NG sequencing, transcriptomics and functional genomics.

Title: Maastricht, Professor & Head, Transplant Immunology.

Role: Expert in HLA, NG sequencing, immunogenetics, and molecular diagnostics

Title: Departments of Statistics and Genetics, University du Quebec a Montreal.

Role: Expertise in Statistical Genetics, Machine Learning, Statistical analysis of high dimensional data, development of Biostatistical software

Title: Dept. Medicine, U. Toronto, Assoc. Director Canadian Blood Services (CBS), Director HLA lab. U. Toronto, Transplant nephrologist

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration

Title: Professor Pathology, Interim Head, Hemato-pathology, Director HLA laboratory, Dalhousie U. Medical Director HLA laboratory, Ottawa. Chair, Canadian HLA Proficiency Testing Committee, Consultant Brazilian Histocompatibility Assn.

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and application to, clinical transplant.

Title: Professor of Medicine, U. Alberta, Chair, CBS National HLA Laboratory Committee; Head, HLA Laboratory U. Alberta Hospitals. President elect American Society of Histocompatibility and Immunogenetics

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.

Title: Principal Scientist, Medicine, clinical nephrologist, U. Montreal

Role: Expert in tissue injury, infection, immunity and inflammation in renal and cardiovascular disease.

Title: Asst. Professor, Dept. Medicine, U. Laval, Endocrinology and nephrology.

Role: Expert in urinary biomarkers, antibody-mediated rejection, immune injury.

Title: Asst. Clinical Professor, Dept. Pathology & Laboratory Medicine, UBC. Assoc. Director, Immunology Laboratory, Vancouver General Hospital.

Role: Expert in HLA, NG sequencing, immunogenetics, Ab detection, flow cytometry and molecular diagnostics

Title: McGill University Health Centre. Director HLA laboratory.

Role: Expert in HLA genetics, immunology and molecular diagnostics for transplantation.

Title: Professor of Laboratory Medicine & Pathology and Head of Department, Alberta. Director of Renal Pathology, U. Alberta Hospitals.

Role: Specialized renal and transplant pathologist. Expert in molecular diagnostics. Board member international Banff process.

Title: Assoc. Prof. of Laboratory Medicine & Pathology, U. Alberta

Role: Specialized renal and transplant pathologist. Expert in vascular injury & molecular diagnostics.

Title: Professor Immunogenetics and Transplantation, U. Leiden. Director, Eurotransplant Reference Laboratory, Leiden.

Role: Expert in HLA, immunogentics, genomics, bioinformatics, international data integration and analysis, sequencing and epitope analysis

Title: Children’s Hospital Oakland. Prior Head, Roche Molecular Diagnostics. Pioneer of PCR reaction and DNA based HLA typing.

Role: Expert in HLA, immunogentics, genomics, bioinformatics, sequencing, epitope analysis and technology development & commercialization.

Title: Professor, Pathology & Laboratory Medicine, Emory U. Co-Director, Histocompatibility & Immunogenetics Labs, Emory Medical Centre.

Role: Expert in HLA, immunogentics, genomics, molecular diagnostics, antibody testing, sequencing and epitope analysis

Title: Professor, Dept. Transplantation Immunology, U. Heidelberg. Director, CTS study, Prior President international Transplantation Society.

Role: Expert in HLA, immunogentics, molecular diagnostics, bioinformatics, international data integration and analysis and epitope analysis

Title: Asst. Prof, Dept. Pathology & Laboratory Medicine, U. N. Carolina. Director, HLA laboratory, UNC Hospitals.

Role: Expert in HLA, NG sequencing, immunogenetics, Ab detection, flow cytometry and molecular diagnostics

Title: Senior Scientist, Dept. Pathology & Laboratory Medicine UBC. Coordinator Genomics, Immunology Laboratory, Vancouver General Hospital.

Role: Expert in HLA, NG sequencing, immunogenetics, Ab detection, flow cytometry and molecular diagnostics

Title: Assoc. Professor Pediatrics, RI-MUHC

Role: Expert in assessing mediation adherence, and will aid in the creation of the pediatric cohort

Title: Professor of Medicine and Pediatrics, U. Toronto

Role: Expert in pediatric transplantation, epidemiology and statistical genetics.

Title: Professeure l’Université de Montréal, Scientific Director, Hema-Quebec

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.

Title: Assoc. Professor of Medicine, Division of Nephrology, U. Montreal

Role: Expert in kidney disease, transplantation, therapeutics and health outcomes.

Title: Clinical Asst. Professor, Medicine UBC. Medical Consultant, Immunogenetics, Immunology Laboratory, UBC Hospitals

Role: Expert in HLA, immunogenetics, NG sequencing and antibody detection. Expert in clinical transplantation and therapeutics.

Research Members: Activity 2

Title: Professor, University of British Columbia (UBC), Medicine and Pathology, Director, Immunology & Founding Head, BC Transplant Program

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.

Title: Scientist, RI-MUHC, Assistant Professor, Department of Medicine, Faculty of Medicine, McGill University

Role: Expert in clinical transplantation, clinical epidemiology, and HLA epitopes.

Title: Dept. Medicine, U. Toronto, Assoc. Director Canadian Blood Services (CBS), Director HLA lab. U. Toronto, Transplant nephrologist

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration

Title: Professor Pathology, Interim Head, Hemato-pathology, Director HLA laboratory, Dalhousie U. Medical Director HLA laboratory, Ottawa. Chair, Canadian HLA Proficiency Testing Committee, Consultant Brazilian Histocompatibility Assn.

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and application to, clinical transplant.

Title: Professor of Medicine, U. Alberta, Chair, CBS National HLA Laboratory Committee; Head, HLA Laboratory U. Alberta Hospitals. President elect American Society of Histocompatibility and Immunogenetics

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.

Title: Principal Scientist, Medicine, clinical nephrologist, U. Montreal

Role: Expert in tissue injury, infection, immunity and inflammation in renal and cardiovascular disease.

Title: Asst. Professor, Dept. Medicine, U. Laval, Endocrinology and nephrology.

Role: Expert in urinary biomarkers, antibody-mediated rejection, immune injury.

Title: Asst. Clinical Professor, Dept. Pathology & Laboratory Medicine, UBC. Assoc. Director, Immunology Laboratory, Vancouver General Hospital.

Role: Expert in HLA, NG sequencing, immunogenetics, Ab detection, flow cytometry and molecular diagnostics

Title: McGill University Health Centre. Director HLA laboratory.

Role: Expert in HLA genetics, immunology and molecular diagnostics for transplantation.

Title: Professor of Laboratory Medicine & Pathology and Head of Department, Alberta. Director of Renal Pathology, U. Alberta Hospitals.

Role: Specialized renal and transplant pathologist. Expert in molecular diagnostics. Board member international Banff process.

Title: Assoc. Prof. of Laboratory Medicine & Pathology, U. Alberta

Role: Specialized renal and transplant pathologist. Expert in vascular injury & molecular diagnostics.

>itle: Professor Immunogenetics and Transplantation, U. Leiden. Director, Eurotransplant Reference Laboratory, Leiden.

Role: Expert in HLA, immunogentics, genomics, bioinformatics, international data integration and analysis, sequencing and epitope analysis

Title: Children’s Hospital Oakland. Prior Head, Roche Molecular Diagnostics. Pioneer of PCR reaction and DNA based HLA typing.

Role: Expert in HLA, immunogentics, genomics, bioinformatics, sequencing, epitope analysis and technology development & commercialization

Title: Professor, Pathology & Laboratory Medicine, Emory U. Co-Director, Histocompatibility & Immunogenetics Labs, Emory Medical Centre.

Role: Expert in HLA, immunogentics, genomics, molecular diagnostics, antibody testing, sequencing and epitope analysis

Title: Professor, Dept. Transplantation Immunology, U. Heidelberg. Director, CTS study, Prior President international Transplantation Society.

Role: Expert in HLA, immunogentics, molecular diagnostics, bioinformatics, international data integration and analysis and epitope analysis

Title: Asst. Prof, Dept. Pathology & Laboratory Medicine, U. N. Carolina. Director, HLA laboratory, UNC Hospitals.

Role: Expert in HLA, NG sequencing, immunogenetics, Ab detection, flow cytometry and molecular diagnostics

Title: Senior Scientist, Dept. Pathology & Laboratory Medicine UBC. Coordinator Genomics, Immunology Laboratory, Vancouver General Hospital.

Role: Expert in HLA, NG sequencing, immunogenetics, Ab detection, flow cytometry and molecular diagnostics

Title: Professor U. Laval, Director Immunology & Histocompatibility Laboratory, CHU de Quebec.

Role: Expert in histocompatibility: HLA typing and laboratory evaluation of immunity

Title: Clin. Assoc. Professor, Dept. Pathology, U. Calgary. Director of Histocompatibility and Immunogenetics Laboratory, U. Calgary Hospitals.

Role: Expert in HLA, NG sequencing, immunogenetics, Ab detection, flow cytometry and molecular diagnostics

Title: Professor Dept. Pathology & Laboratory Medicine, UBC. Director, Heart & Lung Institute, and PROOF Centre (NSERC), UBC.

Role: Expert in transplantation pathology, microvascular injury, molecular genomics, laboratory diagnostics, data analytics, & systems science.

Title: Professor Medical Genetics, UBC. Interim Assoc. Dean, Research UBC. Assoc. Dean Research, Vancouver Coastal Health Research Institute.

Role: Expert in molecular & clinical genetics, transplantation, immunology, molecular sciences and genomics.

Title: Professor of Medicine, U. Montreal. Vice-President Research, U. Montreal, Shire Chair in Nephrology.

Role: Expert in transplantation and AMR, microvascular injury, antibody detection and role of non-HLA ab in kidney injury.

Title: Professor and Interim Head, Dept. Biochemistry and Molecular Biology, UBC. Head, UBC Proteomics Centre.

Role: Expert in proteomics, biochemistry and molecular biology. Member, HuPO Canada program.

Title: Professor Dept. Medical Genetics, UBC. Canada Research Chair in Regenerative Medicine. Prior Head, Biomedical Research Institute, UBC.

Role: Expert in inflammatory cell phenotyping, Mass Cytometry and RNAseq, and stem cell biology.

Title: Director, Genome BC Proteomics Centre, Victoria.

Role: Expert in proteomics, biochemistry and molecular diagnostics in transplantation and medicine.

Title: Assoc. Prof. Microbiology & Immunology, RI-MUHC, Canada Research Chair in Regulatory Lymphocytes of Immune System.

Role: Expert in immune regulation, T-cell biology, immune suppression, and inflammation.

Title: Professor of Pediatrics, Experimental Medicine and Human Genetics. RI-MUHC

Role: Expert in genetics, immune injury, genomics and T-cell receptor sequencing

Title: Professor, Computer Sciences, UBC. CIO, PROOF NSERC Centre, UBC. Director, Data Sciences Program, UBC

Role: Expert in computational science, data analysis, bioinformatics, statistical sciences in genetics, biology and medicine.

Title: Distinguished Professor, U. Medicine Gottingen. Head, Department of Clinical Pharmacology, GA U, Gottingen. Editor, Therapeutic Drug Monitoring.

Role: Expert in pharmacology and transplantation, therapeutic drug monitoring, molecular diagnostics, detection of cell-free DNA as diagnostic methodology.

Title: Professor of Medicine, Immunology & Microbiology, Western U.

Role: Expert in transplantation biology, alloimmunity, molecular sciences, transplant diagnostics, therapeutics and outcomes.

Title: Professor of Biochemistry and Molecular Biology, UBC. Founding Director, Centre for Drug Research and Development, Past Head UBC Life Sciences Centre.

Role: Expert in biochemistry and immunology, genetics, drug testing and development, and development of Precision Medicine.

Title: Professor Dept. Pediatrics, Western U.

Role: Expert in pediatric nephrology & transplantation, therapeutics, pharmacokinetics & pharmacogenomics

Title: Clinical Asst. Professor, Medicine UBC. Medical Consultant, Immunogenetics, Immunology Laboratory, UBC Hospitals

Role: Expert in HLA, immunogenetics, NG sequencing and antibody detection. Expert in clinical transplantation and therapeutics.

Title: Professor of Medicine and Pediatrics, U. Toronto

Role: Expert in pediatric transplantation, epidemiology and statistical genetics.

Title: Professeure l’Université de Montréal , Scientific Director, Hema-Quebec

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.

Research Members: Activity 3

Title: Professor, University of British Columbia (UBC), Medicine and Pathology, Director, Immunology & Founding Head, BC Transplant Program

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.

Title: Scientist, RI-MUHC, Assistant Professor, Department of Medicine, Faculty of Medicine, McGill University

Role: Expert in clinical transplantation, clinical epidemiology, and HLA epitopes.

Title: Senior Scientist, Dept. Pathology & Laboratory Medicine UBC. Coordinator Genomics, Immunology Laboratory, Vancouver General Hospital.

Role: Expert in HLA, NG sequencing, immunogenetics, Ab detection, flow cytometry and molecular diagnostics

Title: Professor of Medicine, Immunology & Microbiology, Western University.

Role: Expert in transplantation biology, alloimmunity, molecular sciences, transplant diagnostics, therapeutics and outcomes.

Title: Professor of Biochemistry and Molecular Biology, UBC. Founding Director, Centre for Drug Research and Development, Past Head UBC Life Sciences Centre.

Role: Expert in biochemistry and immunology, genetics, drug testing and development, and development of Precision Medicine.

Title: Professor Dept. Pediatrics, Western U.

Role: Expert in pediatric nephrology & transplantation, therapeutics, pharmacokinetics & pharmacogenomics.

Title: Associate Professor Pharmaceutical Sciences, UBC.

Role: Expert in systems pharmacology, PK and PK-PD modeling and simulation, and expert in drug development.

Title: Professor of Clinical Pharmacology, U. Rotterdam

Role: Expert in transplantation, pharmacometrics, therapeutic drug monitoring and personalized medicine.

Title: Professor of Medicine & Pharmacology, Limoges. Director of INSERM unit on Pharmacology of Immunosuppression, President-elect International Assn. for Therapeutic Drug Monitoring and Clinical Toxicology.

Role: Expert in medicine and transplantation, clinical pharmacology and therapeutic monitoring, pharmacokinetics / dynamics / genomics, and clinical toxicology.

Title: Vice President, Transplant Services, BSW Health Org. Texas.

Role: Expert in transplantation medicine, pharmacology and therapeutics. Expert in hospital & program administration and technology adoption.

Title: Assoc. Director for Pediatrics, Office of Clinical Pharmacology, US FDA.

Role: Expert in transplantation pharmacology and therapeutic drug monitoring, biomarker development and precision medicine.

Title: Assoc. Professor Pediatrics, RI-MUHC

Role: Expert in assessing mediation adherence, and will aid in the creation of the pediatric cohort.

Title: Professor of Medicine, UBC. Vice President, Canadian Organ Replacement Registry (CORR) at Canadian Institute for Health Information.

Role: Expert in clinical transplant, organ allocation, health outcomes, clinical therapeutics.

Title: Title: Assoc. Professor Medicine, Toronto. Scientist, Institute for Clinical Evaluative Sciences. Head, Kidney Transplant Program, U. Toronto.

Role: Expert, kidney transplant, therapeutics, health outcomes, organ allocation and healthcare evaluation.

Title: Assoc. Professor of Medicine, U Calgary.

Role: Expert in transplant, infection, therapeutics.

Title: Professor of Medicine, U Toronto. Medical Director, University Health Network Transplant Program.

Role: Expert in transplant, infection, therapeutics, program administration.

Title: Clinical Asst. Professor, Medicine UBC. Medical Consultant, Immunogenetics, Immunology Laboratory, UBC Hospitals

Role: Expert in HLA, immunogenetics, NG sequencing and antibody detection. Expert in clinical transplantation and therapeutics.

Title: Assoc. Professor of Medicine, Division of Nephrology, U. Montreal

Role: Expert in kidney disease, transplantation, therapeutics and health outcomes.

Research Members: Activity 4

Title:Professor, University of British Columbia (UBC), Medicine and Pathology, Director, Immunology & Founding Head, BC Transplant Program

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.

Title: Scientist, RI-MUHC, Assistant Professor, Department of Medicine, Faculty of Medicine, McGill University

Role: Expert in clinical transplantation, clinical epidemiology, and HLA epitopes.

Title: Professor, Department of Medicine, Senior Scientist, Centre for Clinical Epidemiology and Evaluation

Role: GELS lead. Expert in health economics, health technology evaluation and cost-effectiveness analysis.

Title: Canada Research Chair in Health Law and Policy; Professor, Faculty of Law and School of Public Health; and Research Director, Health Law Institute, Unbiversity of Alberta

Role: GELS lead; Expert in legal/ethical analyses of emerging technologies; expert in media analyses of health and science policy issues

Title:Assoc. Professor, Operations, Sauder School of Business, UBC

Role: Expert in operations research, economic modeling and simulation, expert in health analysis and transplantation.

Title: Asst. Professor Surgery, RI-MUHC, QT

Role: Expert in clinical transplantation and therapy.

Title: Professor, Center for Applied Pedagogy in the Health Sciences, Faculty of Medicine, Université de Montréal.

Role:Patient expert in transplant, qualitative data collection and analysis, knowledge translation facilitator.

Title: National Director of Research at The Kidney Foundation of Canada

Title:Professor of Medicine, Director of Renal and Pancreas Programs, Dalhousie U.

Role:Expert in kidney transplant, medical decision analysis, economic analysis and clinical transplantation

Title:Asst. Professor of Medicine, Division of Nephrology, Dalhousie U.

Role: Expert in clinical epidemiology and survival analysis including outcomes of kidney transplant candidates/recipients

Title: Associate Professor of Medicine, Division of Nephrology, UBC.

Role: Expert in clinical research in health outcomes and implementation of health policy, clinical transplantation, and health administration.

Title: Asst. Clinical Professor, Division of Nephrology Medicine, U. Montreal.

Role: Expert in ethics and kidney transplantation, qualitative methods, patient partnership in research.

Title: Professor of Medicine, Division of Nephrology, U. Alberta

Role: Expert in kidney disease and transplantation, health care costing and economic analysis.

Title: Dean of Faculty of Pharmaceutical Sciences, U. Otago.

Role: Expert in health services research and decision sciences with a particular emphasis on new molecular technologies.

Title: Director Institute of Health Economics, ELTE, U. Budapest. Prior Director Health Economics, Transplant, Novartis Basle.

Role: Expert in health economics and policy, in transplant therapeutics and innovation.

Title: Professor of Pediatrics, Senior Scientist Genetics and Genome Biology, U. Toronto

Role: Expert in pediatric transplantation, genome analysis and molecular diagnostics.

Title: Assoc. Professor of Medicine, Multi-organ Transplant Program, U. Toronto

Role: Expert in outcomes research, clinical transplantation, cultural and psychosocial aspects of medical care.

Title: Professor of Medicine, UBC. Former President and CEO, Vancouver Coastal Health Authority. Board Member, Canadian Institute for Health Information.

Role: Expert in transplantation medicine (lung), therapeutics, and diagnostics. Expert in health care organization, technology transfer and funding.

Title: Professor of Medicine and Pediatrics, U. Toronto

Role: Expert in pediatric transplantation, epidemiology and statistical genetics.

Title: Professeure l’Université de Montréal, Scientific Director, Hema-Quebec

Role: Expert in HLA typing, laboratory immunity, molecular diagnostics and therapeutics, clinical transplant and health administration.