Activities

Activity 1: Improving Donor Matching Through Epitope Typing

Activity 1: Improving Donor Matching Through Epitope Typing

HLA matching at the epitope level offers new opportunities to identify compatible donors for kidney transplant candidates. It has been demonstrated that transplantation with significant epitope mismatches often result in the formation of new donor specific antibodies...

Activity 2: Identifying Clinical Risk Through Immune Monitoring

Activity 2: Identifying Clinical Risk Through Immune Monitoring

Uremia is accompanied by profound disturbance of the immune response comprising both impaired immune defence and enhanced inflammation. We have shown that this complex picture is explained by profound perturbation of the human transcriptome mediated through the...

Activity 3: Personalizing Treatment Through Systems Pharmacology

Activity 3: Personalizing Treatment Through Systems Pharmacology

Transplant medications have a very narrow therapeutic index (margin between efficacy and toxicity), so that under-treatment may allow rejection while over-treatment causes toxicity. Our research on quantitative pharmacokinetic methods monitoring ADME characteristics...

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