HLA matching at the epitope level offers new opportunities to identify compatible donors for kidney transplant candidates. It has been demonstrated that transplantation with significant epitope mismatches often result in the formation of new donor specific antibodies...
Activities
Activity 2: Identifying Clinical Risk Through Immune Monitoring
Uremia is accompanied by profound disturbance of the immune response comprising both impaired immune defence and enhanced inflammation. We have shown that this complex picture is explained by profound perturbation of the human transcriptome mediated through the...
Activity 3: Personalizing Treatment Through Systems Pharmacology
Transplant medications have a very narrow therapeutic index (margin between efficacy and toxicity), so that under-treatment may allow rejection while over-treatment causes toxicity. Our research on quantitative pharmacokinetic methods monitoring ADME characteristics...
Activity 4: To Inform Health Policy Decisions through Social, Legal and Economic Data
We will use traditional methods of legal scholarship (e.g., the systematic and conceptual analysis of relevant case law, legislation, professional norms, legal theory, etc.) to assess how existing norms and obligations may play out when donor-recipient matching tools...
Join Our Newsletter